Principal AI Systems Engineer

Iovance Biotherapeutics aims to be the global leader in innovating, developing and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer. We are pioneering a transformational approach to treating cancer by harnessing the ability of the human immune system to recognize and attack diverse cancer cells in each patient. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors. We are committed to continuous innovation in cell therapy, including gene-edited cell therapy, which may be a promising option for patients with cancer.

Overview

This is a senior role responsible for the hands-on design, build, validation, and deployment of Artificial Intelligence (AI) systems at Iovance Biotherapeutics. This role is focused on execution — turning approved use cases into working, validated, production AI systems that deliver measurable business value. This role directly supports Iovance's strategy to improve overall operational productivity. The ideal candidate is a deeply technical, hands-on senior engineer with demonstrated production experience designing and shipping Large Language Model (LLM) applications, Retrieval-Augmented Generation (RAG) systems, and modern AI integrations. This position works closely with IT leads, business process owners across Manufacturing, Quality, Regulatory Affairs, Clinical, Commercial, G&A, IT Security, Privacy, and Quality Assurance to deliver AI capabilities that respect Iovance's regulated environment. This role executes against a roadmap and prioritized backlog, while contributing technical input to refinement, scoping, and sequencing.

Primary

Responsibilities

• Design, build, and ship AI systems against the approved Iovance AI roadmap, including end-to-end ownership of architecture, retrieval pipelines, prompts, evaluation, integrations, and deployment for assigned use cases.
• Implement production-grade Retrieval-Augmented Generation (RAG) systems on...